diff --git a/devtools/client/application/test/browser/browser.ini b/devtools/client/application/test/browser/browser.ini
index 8ead171a3429..4150959be496 100644
--- a/devtools/client/application/test/browser/browser.ini
+++ b/devtools/client/application/test/browser/browser.ini
@@ -42,7 +42,7 @@ skip-if = debug # Bug 1559591
 https_first_disabled = true
 skip-if = debug # Bug 1559591
 [browser_application_panel_start-service-worker.js]
-skip-if = asan || debug || !serviceworker_e10s # Bug 1559487, 1559591, 1608640
+skip-if = asan || debug || !serviceworker_e10s || tsan # Bug 1559487, 1559591, 1608640
 [browser_application_panel_list-workers-empty.js]
 [browser_application_panel_list-unicode.js]
 skip-if = debug # Bug 1559591
@@ -68,7 +68,7 @@ skip-if =
   os == 'linux' && bits == 64 && !debug # Bug 1654354
 [browser_application_panel_telemetry-select-page.js]
 [browser_application_panel_telemetry-start-worker.js]
-skip-if = ccov || asan || debug || !serviceworker_e10s # Bug 1559487, 1559591, 1608640, 1654468
+skip-if = ccov || asan || debug || !serviceworker_e10s || tsan # Bug 1559487, 1559591, 1608640, 1654468
 [browser_application_panel_telemetry-unregister-worker.js]
 skip-if = asan || debug || !serviceworker_e10s # Bug 1559487, 1559591, 1608640
 # Misc tests
diff --git a/devtools/client/debugger/test/mochitest/browser.ini b/devtools/client/debugger/test/mochitest/browser.ini
index 664b43dc8421..adfccea12bbe 100644
--- a/devtools/client/debugger/test/mochitest/browser.ini
+++ b/devtools/client/debugger/test/mochitest/browser.ini
@@ -55,7 +55,8 @@ skip-if = (os == "win" && ccov) # Bug 1453549
 [browser_dbg-scroll-run-to-completion.js]
 [browser_dbg-source-pragma.js]
 [browser_dbg-sourcemapped-scopes.js]
-skip-if = ccov || debug || (verify && debug && (os == 'linux')) # Bug 1441545, 1536253 - very slow on debug
+# Bug 1441545, 1536253 - very slow on debug
+skip-if = ccov || debug || tsan || (verify && debug && (os == 'linux'))
 [browser_dbg-sourcemapped-stepping.js]
 skip-if = true # original stepping is currently disabled
 [browser_dbg-sourcemapped-toggle.js]
@@ -76,7 +77,7 @@ skip-if = debug # Window leaks: bug 1575332
 [browser_dbg-breakpoints-list.js]
 [browser_dbg-breakpoints-popup.js]
 skip-if =
-  os == 'linux' && bits == 64 && debug # Bug 1750199
+  (os == 'linux' && debug) || tsan # Bug 1750199
   apple_catalina && !debug # Bug 1767705
 [browser_dbg-continue-to-here.js]
 [browser_dbg-continue-to-here-click.js]
diff --git a/devtools/client/framework/test/browser.ini b/devtools/client/framework/test/browser.ini
index 1597a5b61ed0..a2c3bb0885a4 100644
--- a/devtools/client/framework/test/browser.ini
+++ b/devtools/client/framework/test/browser.ini
@@ -88,8 +88,7 @@ prefs =
 [browser_target_events.js]
 [browser_target_loading.js]
 [browser_target_parents.js]
-skip-if =
-  os == "win" && !debug # Bug 1712697
+skip-if = tsan # bug 1807041
 [browser_target_remote.js]
 [browser_target_support.js]
 [browser_target_get-front.js]
diff --git a/devtools/client/performance-new/test/browser/browser.ini b/devtools/client/performance-new/test/browser/browser.ini
index e3790195e2f0..4f458b020c84 100644
--- a/devtools/client/performance-new/test/browser/browser.ini
+++ b/devtools/client/performance-new/test/browser/browser.ini
@@ -4,6 +4,7 @@ prefs =
   devtools.performance.recording.ui-base-url='http://example.com'
 tags = devtools devtools-performance
 subsuite = devtools
+skip-if = tsan # Bug 1804081, timeouts and data races in various tests
 support-files =
   head.js
   helpers.js
@@ -14,7 +15,6 @@ support-files =
 [browser_aboutprofiling-entries.js]
 [browser_aboutprofiling-features-disabled.js]
 [browser_aboutprofiling-features.js]
-skip-if = tsan # Frequently times out on TSan
 [browser_aboutprofiling-interval.js]
 [browser_aboutprofiling-threads.js]
 [browser_aboutprofiling-threads-behavior.js]
diff --git a/devtools/client/webconsole/test/browser/_browser_console.ini b/devtools/client/webconsole/test/browser/_browser_console.ini
index 720aab41da4d..af6ab2ea93db 100644
--- a/devtools/client/webconsole/test/browser/_browser_console.ini
+++ b/devtools/client/webconsole/test/browser/_browser_console.ini
@@ -21,6 +21,7 @@ support-files =
 [browser_console.js]
 [browser_console_and_breakpoints.js]
 [browser_console_clear_cache.js]
+skip-if = tsan # Bug 1479876
 [browser_console_clear_closed_tab.js]
 [browser_console_clear_method.js]
 skip-if = true # Bug 1437843
diff --git a/devtools/client/webconsole/test/browser/_jsterm.ini b/devtools/client/webconsole/test/browser/_jsterm.ini
index ac2e0baacc54..5f1262229949 100644
--- a/devtools/client/webconsole/test/browser/_jsterm.ini
+++ b/devtools/client/webconsole/test/browser/_jsterm.ini
@@ -61,6 +61,7 @@ skip-if = (os == "win" && os_version == "6.1") # Bug 1620521
 [browser_jsterm_autocomplete_native_getters.js]
 [browser_jsterm_autocomplete_nav_and_tab_key.js]
 [browser_jsterm_autocomplete_null.js]
+skip-if = tsan # bug 1778033
 [browser_jsterm_autocomplete_paste_undo.js]
 [browser_jsterm_autocomplete_race_on_enter.js]
 [browser_jsterm_autocomplete_return_key_no_selection.js]
@@ -76,7 +77,9 @@ skip-if = debug && (os == "win" && bits == 32) # Bug 1620856
 [browser_jsterm_await_error.js]
 [browser_jsterm_await_helper_dollar_underscore.js]
 [browser_jsterm_await_paused.js]
-skip-if = debug # crashes on "Unexpected UpdateTransformLayer hint" bug 1570685
+skip-if =
+  debug # crashes on "Unexpected UpdateTransformLayer hint" bug 1570685
+  tsan # bug 1807140
 [browser_jsterm_await.js]
 [browser_jsterm_block_command.js]
 [browser_jsterm_completion_bracket_cached_results.js]
diff --git a/devtools/client/webconsole/test/browser/_webconsole.ini b/devtools/client/webconsole/test/browser/_webconsole.ini
index b69ee02a7e7f..ff85c539870c 100644
--- a/devtools/client/webconsole/test/browser/_webconsole.ini
+++ b/devtools/client/webconsole/test/browser/_webconsole.ini
@@ -215,6 +215,7 @@ skip-if = true # Bug 1405250
 [browser_webconsole_console_group_open_no_scroll.js]
 [browser_webconsole_console_group.js]
 [browser_webconsole_console_logging_workers_api.js]
+skip-if = tsan # Bug 1767724
 [browser_webconsole_console_profile_unavailable.js]
 [browser_webconsole_console_table_post_alterations.js]
 [browser_webconsole_console_table.js]
diff --git a/devtools/server/tests/browser/browser.ini b/devtools/server/tests/browser/browser.ini
index 1994ab11ea52..ed43a65a9b5d 100644
--- a/devtools/server/tests/browser/browser.ini
+++ b/devtools/server/tests/browser/browser.ini
@@ -128,9 +128,13 @@ skip-if =
 [browser_layout_simple.js]
 [browser_memory_allocations_01.js]
 [browser_perf-01.js]
+skip-if = tsan # bug 1804081, profiler issues in TSAN
 [browser_perf-02.js]
+skip-if = tsan # bug 1804081, profiler issues in TSAN
 [browser_perf-04.js]
+skip-if = tsan # bug 1804081, profiler issues in TSAN
 [browser_perf-getSupportedFeatures.js]
+skip-if = tsan # bug 1804081, profiler issues in TSAN
 [browser_setup_in_parent.js]
 [browser_spawn_actor_in_parent.js]
 [browser_storage_cookies-duplicate-names.js]
@@ -139,6 +143,7 @@ https_first_disabled = true
 https_first_disabled = true
 skip-if =
   debug # Bug 1715916 - test is having race conditions on slow hardware
+  tsan # high frequency intermittent
   win10_2004 && asan && fission # high frequency intermittent
   win11_2009 && asan # high frequency intermittent
 [browser_storage_listings.js]
diff --git a/taskcluster/ci/test/mochitest.yml b/taskcluster/ci/test/mochitest.yml
index a70dd7175b34..9f270525b40d 100644
--- a/taskcluster/ci/test/mochitest.yml
+++ b/taskcluster/ci/test/mochitest.yml
@@ -390,7 +390,6 @@ mochitest-devtools-chrome:
             default:
                 by-test-platform:
                     android.*: []
-                    .*-tsan-qr/opt: []
                     linux.*64-ccov-qr/opt: []
                     default: built-projects
     tier: default