diff --git a/build/moz.configure/init.configure b/build/moz.configure/init.configure
index 87120573a0cc..bfb878aebb78 100644
--- a/build/moz.configure/init.configure
+++ b/build/moz.configure/init.configure
@@ -739,11 +739,10 @@ def real_target(value, host, shell, project, application):
         project = project[0]
     if not value:
         if project == "mobile/android":
-            target_cpu, target_system = (
-                ("aarch64", "android")
-                if host.cpu == "aarch64"
-                else ("arm", "androideabi")
-            )
+            target_cpu, target_system = {
+                "aarch64": ("aarch64", "android"),
+                "x86_64": ("x86_64", "android"),
+            }.get(host.cpu, ("arm", "androideabi"))
             return split_triplet(f"{target_cpu}-unknown-linux-{target_system}")
         if project == "mobile/ios":
             return split_triplet("aarch64-apple-ios")
diff --git a/python/mozbuild/mozbuild/test/configure/test_moz_configure.py b/python/mozbuild/mozbuild/test/configure/test_moz_configure.py
index 7bb1b927e077..c10adb3b476d 100644
--- a/python/mozbuild/mozbuild/test/configure/test_moz_configure.py
+++ b/python/mozbuild/mozbuild/test/configure/test_moz_configure.py
@@ -28,6 +28,8 @@ class TargetTest(BaseConfigureTest):
             platform = "win32"
         elif "openbsd6" in self.HOST:
             platform = "openbsd6"
+        elif "apple-darwin" in self.HOST:
+            platform = "darwin"
         else:
             raise Exception("Missing platform for HOST {}".format(self.HOST))
         sandbox = self.get_sandbox({}, {}, args, env, cls=sandbox_class(platform))
@@ -111,7 +113,7 @@ class TestTargetAndroid(TargetTest):
     def test_target(self):
         self.assertEqual(
             self.get_target(["--enable-project=mobile/android"]),
-            "arm-unknown-linux-androideabi",
+            "x86_64-unknown-linux-android",
         )
         self.assertEqual(
             self.get_target(["--enable-project=mobile/android", "--target=i686"]),
@@ -131,6 +133,16 @@ class TestTargetAndroid(TargetTest):
         )
 
 
+class TestTargetAndroidAppleSiliconHost(TargetTest):
+    HOST = "aarch64-apple-darwin"
+
+    def test_target(self):
+        self.assertEqual(
+            self.get_target(["--enable-project=mobile/android"]),
+            "aarch64-unknown-linux-android",
+        )
+
+
 class TestTargetOpenBSD(TargetTest):
     # config.guess returns amd64 on OpenBSD, which we need to pass through to
     # config.sub so that it canonicalizes to x86_64.