diff --git a/taskcluster/ci/config.yml b/taskcluster/ci/config.yml
index 20d0450a5c0a..870752d2462c 100644
--- a/taskcluster/ci/config.yml
+++ b/taskcluster/ci/config.yml
@@ -64,8 +64,6 @@ treeherder:
         'M-1proc': 'Mochitests without e10s or fission'
         'M-a11y-checks': 'Mochitests with accessibility checks enabled'
         'M-a11y-checks-nofis': 'Mochitests with accessibility checks enabled and without fission enabled'
-        'M-a11y-no-cache': 'Mochitests with accessibility cache disabled'
-        'M-a11y-no-cache-1proc': 'Mochitests with accessibility cache, e10s, and fission disabled'
         'M-xorig': 'Mochitests with cross-origin and fission enabled'
         'M-gli': 'Mochitests with WebGL over IPC'
         'M-gli-nofis': 'Mochitests with WebGL over IPC without fission enabled'
diff --git a/taskcluster/ci/test/mochitest.yml b/taskcluster/ci/test/mochitest.yml
index 5fd3ce8fdead..6f0e638f03f0 100644
--- a/taskcluster/ci/test/mochitest.yml
+++ b/taskcluster/ci/test/mochitest.yml
@@ -193,7 +193,6 @@ mochitest-a11y:
         - 1proc
         - socketprocess_networking+1proc
         - webrender-sw+1proc
-        - a11y-no-cache+1proc
         - editor-legacy-direction
     run-on-projects:
         by-variant:
@@ -206,7 +205,6 @@ mochitest-a11y:
                     android-em-7.0-x86_64-qr/debug: built-projects
                     linux.*64-qr/debug: built-projects
                     default: []
-            a11y-no-cache+1proc: ['trunk']
             1proc: built-projects
             editor-legacy-direction:
                 by-test-platform:
@@ -315,18 +313,10 @@ mochitest-browser-a11y:
     treeherder-symbol: M(ba)
     schedules-component: mochitest-browser-a11y
     loopback-video: true
-    variants:
-        - a11y-no-cache
     run-on-projects:
-        by-variant:
-            a11y-no-cache:
-                by-test-platform:
-                    android.*: []
-                    default: ["trunk"]
-            default:
-                by-test-platform:
-                    android.*: []
-                    default: built-projects
+        by-test-platform:
+            android.*: []
+            default: built-projects
     tier: default
     max-run-time:
         by-test-platform:
diff --git a/taskcluster/ci/test/variants.yml b/taskcluster/ci/test/variants.yml
index 5dab8cd9b061..9777cc3ceca6 100644
--- a/taskcluster/ci/test/variants.yml
+++ b/taskcluster/ci/test/variants.yml
@@ -267,16 +267,6 @@ wmf-media-engine:
                 - "--setpref=media.wmf.media-engine.enabled=true"
                 - "--setpref=media.wmf.media-engine.channel-decoder.enabled=true"
 
-a11y-no-cache:
-    description: "{description} with accessibility cache disabled"
-    component: "Core::Disability Access APIs"
-    expiration: "2023-08-01"
-    suffix: "a11y-no-cache"
-    merge:
-        mozharness:
-            extra-options:
-                - "--setpref=accessibility.cache.enabled=false"
-
 msix:
     description: "{description} from msix packages"
     component: "Firefox:Installer"